Depression: A Risk Factor for Non-cardiovascular and Cardiovascular Disease

Here are some of what Cousins Center investigators have found:

Depression alters the immune system and risk for infectious disease.
Irwin M: Immune correlates of depression. Advances in Experimental Medicine and Biology 461:1-24, 1999.
Irwin M, Costlow C, Williams H, Artin KH, Chan CY, Stinson D, Levin MJ, Hayward AR,Oxman M: Cellular immunity to varicella-zoster virus in patients with major depression. J Infectious Diseases 178 (Suppl 1):S104-108, 1998.
Depression leads to inflammation: role in cardiovascular disease
Lesperance F, Frasure-Smith N, Theroux P, Irwin M . The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. Am J Psychiatry 161(2): 271-7, 2004.
Gage, J. R., G. C. Fonarow, M. Hamilton, O. Martínez-Maza, and D. L. Vredevoe. 2004. Beta blocker and Angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation 11:173-180.
The utility of yoga asanas in decreasing symptoms of depression and improving mood
Woolery A, Myers H, Sternlieb B, Zeltzer LK: A yoga intervention for young adults with elevated symptoms of depression, Alternative Therapies in Health & Medicine, 2004; 10, 60-63.
Immune activation and depression predict disease severity in rheumatoid arthritis patients
Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol 31 (3):457-63, 2004.
Inflammatory Markers and Sleep Disturbance in Major Depression
Motivala , S.J., Sarfatti, A., Olmos, L., & Irwin, M. (in press). Inflammatory Markers and Sleep Disturbance in Major Depression. Psychosomatic Medicine.
Here are some of our ongoing studies:
Depression and Trial of Varicella Vaccine in the Elderly - Click here
Michael Irwin, Principal Investigator
New PDF in the Psychosomatic Medicine Journal
Research : Sponsored Studies : Depression
Study Participation
Sponsored Studies
Seed Grant Program
Core Laboratories