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| Research : | Sponsored Studies : | Infectious Diseases & HIV / AIDS |
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Infectious Disease: Psychological and Biological Mechanisms of Disease Risk
Here is what Cousins Center investigators have found: |
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| Psychological risk factors can increase autonomic activation and lead to increases of viral load in patients with human immunodeficiency virus (HIV) | |
| • | Cole SW, Kemeny ME, Fahey JL, Zack JA and Naliboff BD. Psychological risk factors for HIV pathogenesis: Mediation by the autonomic nervous system. Biol Psychiatry. 2003 Dec 15;54(12):1444-56. |
| • | Cole SW , Naliboff BD, Kemeny ME, Griswold M, Fahey JL, & Zack JA. Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity . PNAS USA, 98, 12695-12700, 2001. |
| • | Brownley, K.A., Milanovich, J.R., Motivala, S.J., Schneiderman, N., Fillion, L., Graves, J.A., Klimas, N., Fletcher, M.A. & Hurwitz, B.E. Autonomic and cardiovascular function in HIV spectrum disease: early indications of cardiac pathophysiology. Clinical Autonomic Research, 11(5):319-26, 2001. |
| HIV-related processes disrupt CNS and immune system communication | |
| • | Motivala SJ, Hurwitz BE, Llabre MM, Klimas NG, Fletcher MA, Antoni MH, LeBlanc WG, Schneiderman N. Psychological distress is associated with decreased memory helper T-cell and B-cell counts in pre-AIDS HIV seropositive men and women but only in those with low viral load . Psychosomatic Medicine 65(5): 627-635, 2003. |
| Depression lowers immunity to herpes zoster or shingles | |
| • | Irwin M, Costlow C, Williams H, Artin KH, Chan CY, Stinson D, Levin MJ, Hayward AR,Oxman M: Cellular immunity to varicella-zoster virus in patients with major depression. J Infectious Diseases 178 (Suppl 1):S104-108, 1998. |
| The practice of Tai Chi Chih, a moving meditation, improves health functioning and immunity in older adults with herpes zoster | |
| • | Irwin MR , PikeJL, Cole, JS & Oxman M. Effects of a behavioral intervention, Tai Chi Chih, on Varicella zoster virus specific immunity and health functioning in older and at-risk adults. Psychosomatic Medicine, 65:824-830, 2003. |
| Post-operative infections are more likely to occur in alcoholics with abnormal cytokine expression. | |
| • | Sanders M, Irwin M, Sinha P, Naumann E, Kern H, Kox WJ, Spies CD: Suppresion of Interleukin-6 to interluekin-10 ratio in chronic alcoholics: association with postoperative infections. Intensive Care Med 28:285-292, 2002. (8 pages) |
| See what we are doing now. Here are some of our ongoing studies: | |
| • | CD8 T Cell Replicative Senescence and HIV Disease PI: Rita Effros Funded by NIAID |
| • | Immune Dysfunction and AIDS-associated B Cell Lymphoma PI: Otoniel Martinez-Maza Funded by NCI |
| • | Molecular Epidemiology of AIDS-associated Lymphoma PI: Otoniel Martinez-Maza Funded by NCI |
| • | Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL PI: Otoniel Martinez-Maza Funded by NCI |
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