Inflammation: Psychological Risk for Disease and Symptom Severity

Here is what Cousins Center investigators have accomplished:

Pain and non-restful sleep lead to fatigue in fibromyalgia patients.
Nicassio PM, Moxham EG, Schuman CE, Gevirtz RN. The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain 2002 Dec;100(3):271-9
Diminished beta-adrenergic receptors function is associated with the chronic state of fibromyalgia syndrome
Maekawa K, Twu C, Lotaif A, ChiappelliF, Clark G. Function of beta adrenergic receptor on mononuclear cells in female Fibromyalgia patients Preliminary report. 2003, Journal of Rheumatology, 2003, 30:364-8.
Immune activation and depression predict disease severity in rheumatoid arthritis patients
Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol 31 (3):457-63, 2004. 
Social inhibition leads to heightened immune responses during social engagement
Cole S, Kemeny ME, Weitzman ME, Schoen M, Anton PA. Socially inhibited individuals show heightened DTH response during intense social engagement. Brain, Behavior and Immunity, 13(2):187-200, 1999.
Chronic stress worsens colitis in an animal model
Mulugeta M, Taché Y,AntonPA. Chronic stress worsens TNB colitis in Lewis rats: The protective role of brain CRF. Am J Physiol, 276:G1016, 1999.
Low grade mucosal inflammation alone is unlikely to be responsible for symptoms in functional gastrointestinal disorders
Chang L, Munakata J, Naliboff B, Saba L, Matin K, Bernstein C, AntonPA, Mayer EA. Perceptual responses in patients with inflammatory and functional bowel disease. Gut, 47:497-505, 2000.
IBS patients show altered brain responses to rectal stimuli, regardless of whether stimuli are delivered or anticipated
Naliboff BD , Derbyshire SWG, Munakata J, Berman S, Mandelkern M, Chang L, Mayer EA. Cerebral activation in irritable bowel syndrome patients and control subjects during rectosigmoid distension. Psychosomatic Medicine, 63: 365-375, 2001.
IBS patients may have an altered central release of endogenous opioids in response to visceral stimulation
Lembo A, Naliboff BD, Matin K, Munakata J, Parker R, Gracely R, Mayer EA. Irritable bowel syndrome patients show altered sensitivity to exogenous opioid. Pain, 1195-1200, 2000.
Relationship factors, health beliefs, and health status may help explain treatment intentions among the chronically ill
Goldring AB , Taylor SE, Kemeny ME, AntonPA. Impact of health beliefs, quality of life, and the physician-patient relationship on the treatment intentions of inflammatory bowel disease patients . Health Psychology, 2002 May;21(3):219-28.
Psychobiological views on “stress-related oral ulcers”
Chiappelli F , Cajulis OS. Psychobiological views on “stress-related oral ulcers”. Quintessence International, 2004, 35:223-7.
See what we are doing now. Here are some of our ongoing studies:
Sleep and Immune Mechanisms in Rheumatoid Arthritis
PI: Michael Irwin Funded by NHLBI
Behavioral Treatments in Rheumatoid Arthritis
PI: Perry Nicassio Funded by NIAMSD
Efficacy of CAM Interventions in Rheumatoid Arthritis
PI: Jennifer Pike Funded by NCCAM
Research : Sponsored Studies : Autoimmune and Inflammatory Disorders
Study Participation
Sponsored Studies
Seed Grant Program
Core Laboratories