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Inflammation: Psychological Risk for Disease and Symptom Severity
Here is what Cousins Center investigators have accomplished: |
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| Pain and non-restful sleep lead to fatigue in fibromyalgia patients. | |
| • | Nicassio PM, Moxham EG, Schuman CE, Gevirtz RN. The contribution of pain, reported sleep quality, and depressive symptoms to fatigue in fibromyalgia. Pain 2002 Dec;100(3):271-9 |
| Diminished beta-adrenergic receptors function is associated with the chronic state of fibromyalgia syndrome | |
| • | Maekawa K, Twu C, Lotaif A, ChiappelliF, Clark G. Function of beta adrenergic receptor on mononuclear cells in female Fibromyalgia patients Preliminary report. 2003, Journal of Rheumatology, 2003, 30:364-8. |
| Immune activation and depression predict disease severity in rheumatoid arthritis patients | |
| • | Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol 31 (3):457-63, 2004. |
| Social inhibition leads to heightened immune responses during social engagement | |
| • | Cole S, Kemeny ME, Weitzman ME, Schoen M, Anton PA. Socially inhibited individuals show heightened DTH response during intense social engagement. Brain, Behavior and Immunity, 13(2):187-200, 1999. |
| Chronic stress worsens colitis in an animal model | |
| • | Mulugeta M, Taché Y,AntonPA. Chronic stress worsens TNB colitis in Lewis rats: The protective role of brain CRF. Am J Physiol, 276:G1016, 1999. |
| Low grade mucosal inflammation alone is unlikely to be responsible for symptoms in functional gastrointestinal disorders | |
| • | Chang L, Munakata J, Naliboff B, Saba L, Matin K, Bernstein C, AntonPA, Mayer EA. Perceptual responses in patients with inflammatory and functional bowel disease. Gut, 47:497-505, 2000. |
| IBS patients show altered brain responses to rectal stimuli, regardless of whether stimuli are delivered or anticipated | |
| • | Naliboff BD , Derbyshire SWG, Munakata J, Berman S, Mandelkern M, Chang L, Mayer EA. Cerebral activation in irritable bowel syndrome patients and control subjects during rectosigmoid distension. Psychosomatic Medicine, 63: 365-375, 2001. |
| IBS patients may have an altered central release of endogenous opioids in response to visceral stimulation | |
| • | Lembo A, Naliboff BD, Matin K, Munakata J, Parker R, Gracely R, Mayer EA. Irritable bowel syndrome patients show altered sensitivity to exogenous opioid. Pain, 1195-1200, 2000. |
| Relationship factors, health beliefs, and health status may help explain treatment intentions among the chronically ill | |
| • | Goldring AB , Taylor SE, Kemeny ME, AntonPA. Impact of health beliefs, quality of life, and the physician-patient relationship on the treatment intentions of inflammatory bowel disease patients . Health Psychology, 2002 May;21(3):219-28. |
| Psychobiological views on “stress-related oral ulcers” | |
| • | Chiappelli F , Cajulis OS. Psychobiological views on “stress-related oral ulcers”. Quintessence International, 2004, 35:223-7. |
| See what we are doing now. Here are some of our ongoing studies: | |
| • | Sleep and Immune Mechanisms in Rheumatoid Arthritis PI: Michael Irwin Funded by NHLBI |
| • | Behavioral Treatments in Rheumatoid Arthritis PI: Perry Nicassio Funded by NIAMSD |
| • | Efficacy of CAM Interventions in Rheumatoid Arthritis PI: Jennifer Pike Funded by NCCAM |
| Research : | Sponsored Studies : | Autoimmune and Inflammatory Disorders |
