Substance Dependence: Biobehavioral Mechanisms and Infectious Disease Risk

Here is what our Cousins Center investigators have accomplished:

Alcoholism: Poor sleep is associated with autonomic and endocrine dysregulation
Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependenceIrwin MR, Valladares EM, et al., Psychosom Med. 2006 Jan-Feb; 68(1): 159-66.PMID: 16449427 [PubMed – indexed for MEDLINE]

Visual EEG differences in abstinent alcohol dependence and ethnicity Valladares EM, Irwin M, Sleep Med. 2006 Jan; 7(1): 79-80. Epub 2005 Nov 28. No abstract available.PMID: 16314146 [PubMed – indexed for MEDLINE]

Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics Irwin MR, Ziegler M, Hypertension. 2005 Feb; 45(2): 252-7. Epub 2005 Jan 10.PMID: 15642774 [PubMed – indexed for MEDLINE]

Effects of alcohol intake on circadian processes

Differential effects of alcohol consumption and withdrawal on circadian temperature and activity rhythms in Sprague-Dawley, Lewis, and Fischer male and female rats. Taylor AN, Tio DL, et al., Alcohol Clin Exp Res. 2006 Mar; 30(3): 438-47.PMID: 16499484 [PubMed – indexed for MEDLINE]

Cocaine use and autonmic and inflammtoary activity
Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms. Irwin MR, Olmos L, et al., J Pharmacol Exp Ther. 2007 Feb; 320(2): 507-15. Epub 2006 Oct 26.PMID: 17068203 [PubMed – in process]

Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Newton TF, De La Garza R 2 nd, et al., Pharmacol Biochem Behav. 2005 Sep; 82(1): 90-7. Epub 2005 Aug 19.PMID: 16112720 [PubMed – indexed for MEDLINE]

Opiates: neural plasticity, addictive behavior and tolerance
Secrets of the opium poppy revealed.Evans CJ, Neuropharmacology. 2004; 47 Suppl 1: 293-9. Review. PMID: 15464145 [PubMed – indexed for MEDLINE]

Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice. Bryant CD, Roberts KW, et al., Pharmacol Biochem Behav. 2006 Dec; 85(4): 769-79. Epub 2006 Dec 28.PMID: 17196637 [PubMed – in process]

See what we are doing now. Here are some of our ongoing studies:
Hyperalgesia in Methadone Patients: Can it be Treated?
PI: Margaret Compton Funded by NIDA
Center for Study of Opioid Receptors and Drugs of Abuse
PI: Christopher Evans Funded by NIDA
Assess of Stress Effects in Methamphetamine Dependence
PI: Thomas Newton Funded by NIDA
Laboratory Models of Cocaine Self-Administration
PI: Thomas Newton Funded by NIDA
Perindopril-Methamphetamine Interaction Study
PI: Thomas Newton Funded by NIDA
Clinical Research Education for Drug Abuse Professionals
PI: Thomas Newton Funded by NIDA
Research : Sponsored Studies : Alcoholism and Substance Abuse
Study Participation
Sponsored Studies
Seed Grant Program
Core Laboratories