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Substance Dependence: Biobehavioral Mechanisms and Infectious Disease Risk
Here is what our Cousins Center investigators have accomplished: |
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| Alcoholism: Poor sleep is associated with autonomic and endocrine dysregulation | |
| • | Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependenceIrwin MR, Valladares EM, et al., Psychosom Med. 2006 Jan-Feb; 68(1): 159-66.PMID: 16449427 [PubMed – indexed for MEDLINE] |
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Visual EEG differences in abstinent alcohol dependence and ethnicity Valladares EM, Irwin M, Sleep Med. 2006 Jan; 7(1): 79-80. Epub 2005 Nov 28. No abstract available.PMID: 16314146 [PubMed – indexed for MEDLINE] |
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Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics Irwin MR, Ziegler M, Hypertension. 2005 Feb; 45(2): 252-7. Epub 2005 Jan 10.PMID: 15642774 [PubMed – indexed for MEDLINE] |
| Effects of alcohol intake on circadian processes | |
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Differential effects of alcohol consumption and withdrawal on circadian temperature and activity rhythms in Sprague-Dawley, Lewis, and Fischer male and female rats. Taylor AN, Tio DL, et al., Alcohol Clin Exp Res. 2006 Mar; 30(3): 438-47.PMID: 16499484 [PubMed – indexed for MEDLINE] |
| Cocaine use and autonmic and inflammtoary activity | |
| • | Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms. Irwin MR, Olmos L, et al., J Pharmacol Exp Ther. 2007 Feb; 320(2): 507-15. Epub 2006 Oct 26.PMID: 17068203 [PubMed – in process] |
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Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Newton TF, De La Garza R 2 nd, et al., Pharmacol Biochem Behav. 2005 Sep; 82(1): 90-7. Epub 2005 Aug 19.PMID: 16112720 [PubMed – indexed for MEDLINE] |
| Opiates: neural plasticity, addictive behavior and tolerance | |
| • | Secrets of the opium poppy revealed.Evans CJ, Neuropharmacology. 2004; 47 Suppl 1: 293-9. Review. PMID: 15464145 [PubMed – indexed for MEDLINE] |
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Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice. Bryant CD, Roberts KW, et al., Pharmacol Biochem Behav. 2006 Dec; 85(4): 769-79. Epub 2006 Dec 28.PMID: 17196637 [PubMed – in process] |
| See what we are doing now. Here are some of our ongoing studies: | |
| • | Hyperalgesia in Methadone Patients: Can it be Treated? PI: Margaret Compton Funded by NIDA |
| • | Center for Study of Opioid Receptors and Drugs of Abuse PI: Christopher Evans Funded by NIDA |
| • | Assess of Stress Effects in Methamphetamine Dependence PI: Thomas Newton Funded by NIDA |
| • | Laboratory Models of Cocaine Self-Administration PI: Thomas Newton Funded by NIDA |
| • | Perindopril-Methamphetamine Interaction Study PI: Thomas Newton Funded by NIDA |
| • | Clinical Research Education for Drug Abuse Professionals PI: Thomas Newton Funded by NIDA |
| Research : | Sponsored Studies : | Alcoholism and Substance Abuse |
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