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| About Us : | Faculty : | Martinez |
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Otoniel Martínez-Maza, PhD Research Interests and Current Projects: A major objective of Dr. Martínez-Maza’s work over the last several years has been to define HIV infection-associated immune system changes that precede, and contribute to, AIDS-associated non-Hodgkins |
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B cell lymphoma (AIDS-lymphoma). This includes studies to determine if elevated levels of B cell-stimulatory cytokines precede the development of AIDS-lymphoma, and/or if polymorphisms in the genes encoding B cell-stimulatory cytokines are associated with an elevated risk for the development of AIDS-lymphoma. In recent work, it was seen that elevated IL10 production, as well as a genetic predisposition toward higher production of IL10 (an IL10 promoter SNP at -592 associated with relatively higher expression of this cytokine), were risk factors for the development of AIDS-lymphoma. In other work, his group is examining the role of activation-induced cytidine deaminase (AICDA) in the pathogenesis of AIDS-lymphoma. In recent work, an AICDA splice variant was identified, and current studies aim to better identify its function. Additionally, the induction of AICDA expression by human viruses (EBV) is being explored. Finally, Dr. Martínez-Maza also is involved in studies to better define the role of immune dysfunction in the pathogenesis of gynecologic cancers, including those associated with human papillomavirus (HPV) infection. Dr. Martínez-Maza is actively involved in several national and international multicenter studies of cancer, or AIDS and HIV infection. He serves as the Chairman of the Malignancies Working Group in the Multicenter AIDS Cohort Study, and participates in the AIDS Malignancies Consortium and in Interlymph, an international consortium of researchers with an interest in the epidemiology and pathogenesis of lymphoma. In addition to this, he is the director of the NIH/Fogarty-funded AIDS-malignancies supplemental program supporting international training and research in this area. Rapkin, A., M. Morgan, C. Bonpane, and O. Martinez-Maza. 2000. Peritoneal fluid interleukin-6 in women with chronic pelvic pain. Fertility and Sterility 74:325-328. Gage, J., A. K. Sandhu, M. Nihira, M. Da Gloria Bonecini-Almeida, P. Cristoforoni, T. Kishimoto, F. J. Montz, and O. Martínez-Maza. 2000. Cervical cancer cell lines and human papillomavirus- (HPV) immortalized keratinocytes induce HIV-1 in the U1 monocytic line. Obstetrics & Gynecology 96:879-885. Breen, E. C., J. R. Gage, B. Guo, L. Magpantay, M. Narazaki, T. Kishimoto, S. Miles, and O. Martínez-Maza. 2001. Viral IL6 stimulates human peripheral blood B cells that are unresponsive to human IL6. Cellular Immunology 212:118-125. Martínez-Maza, O. and E. C. Breen. 2002. B cell activation and lymphoma in HIV patients. Current Opinion in Oncology 14:528-532. Breen, E. C., W. J. Boscardin, R. Detels, L. P. Jacobson, M. W. Smith, J. S. Chmiel, C. Rinaldo, S. Lai, and O. Martinez-Maza. 2003. The development of AIDS-associated non-Hodgkin’s B cell lymphoma is preceded by increased serum IL10 and is associated with a high-expressor IL10 genotype. Clinical Immunology 109:119-129. Gage, J. R., G. C. Fonarow, M. Hamilton, O. Martínez-Maza, and D. L. Vredevoe. 2004. Beta blocker and Angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation 11:173-180. Cozen, W., P. S. Gill, S. A. Ingles, R. Masood, O. Martinez-Maza, M. G. Cockburn, J. Gauderman, L. Bernstein, M. C. Pike, B. Nathwani, M. T. Towhid Salam, K. Danley, W. Wang, J. Gage, S. Gundell-Miller and T. M. Mack. 2004. IL-6 phenotype and genotype are associated with decreased risk of young adult Hodgkin’s disease. Blood 103:3216-3221. Contact Information: |
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