Alicia Collado-Hidalgo,Ph.D.

Brief Biography
I am originally form Madrid, Spain, and I received my bachelor’s degree in science at the Universidad Complutense of Madrid. Form there I went to Indiana University were I completed my Ph.D. degree in Genetics with a minor in Cell Biology, under the direction of Dr. Error! Bookmark not defined.. My graduate studies focused on the regulation of

indoleamine 2,3-deoxygenase (INDO) by interferon-gamma (IFN-?), with special interest on transcriptional regulators of IFN-? signaling.

I started my postdoctoral training at UCLA, in Dr. Tim Lane laboratory, studying the effects of TGF-? on breast cancer progression utilizing a wnt over-expressing transgenic mouse model, focusing on the cross-talk interaction of the TGF-? and the wnt signaling pathways.

I am currently a postdoctoral fellow at the Cousins Center for PNI working under the direction of Dr. Steve Cole.

Brief Description of Research Project
Under the direction of Dr. Steve Cole we propose to study the inflammatory processes underlying negative behavioral sequelae of breast cancer. Previous studies indicate that fatigued breast cancer survivors show elevated markers of inflammation that correlate with increased numbers of circulating T-lymphocytes, suggesting an underlying immunologic cause. However, fatigued breast cancer survivors showed no signs or symptoms of illness that could account for the immune alterations. Sub-clinical pathology such as a low-grade viral infection could be responsible the increased T-lymphocytes levels, but it is also possible that the cancer therapy itself has produced long-term alterations in leukocyte production or homeostasis. With this proposal we intend to discriminate between these two possibilities. We aim to define the origin of the immune alteration by: 1) evaluating the clonality of T lymphocyte expansion (oligoclonal expansion suggests an antigen-driven process whereas polyclonal expansion is more consistent with a global homeostatic change); 2) quantifying changes in circulating T-lymphocyte levels and phenotype, and 3) analyzing T lymphocyte differentiation to non-functional states (e.g., anergy or apoptosis).