Francesco Chiappelli, Ph.D.
Professor, UCLA School of Dentistry
Division of Oral Biology and Medicine, Laboratory of Human Oral and
Molecular Immunology
Associate Member, Cousins Center for Psychoneuroimmunology,
UCLA Neuropsychiatric Institute
Current Research
co-Principal Investigator
Merit Review ( Taylor), VAMC
Alcoholism and brain-immune interactions
This project studies the molecular events that determine the mechanisms of modulation of brain-immune interactions by alcohol and alcohol abuse.
Associate Director
1 R24 AT002681 (Mayer), NIH
Mind/Brain/Body Interactions in Stress-Related Disorders
My role on this infrastructure grant is that of Associate Director for the Health Outcome core (Evidence-Based Medicine, Neuro-immune Interactions). The goal of this infrastructure grant is to develop 4 research cores (Health Outcomes, Neuroimaging, Animal Models, Psychophysiology and Pain Assessment) to provide novel, cutting edge expertise and technologies to UCLA investigators interested in the study of mind brain body interactions. After the full build up of the cores, there will be a Pilot and Feasibility program for years 3-5 of the grant with 4 annual awards. These projects will utilize the resources of the cores as well as the expertise of the involved faculty. In addition, a career development program in form of a Named New Investigator award is included, as well as several developmental and public infrastructure components.
Principal Investigator
IIRG 1064, Alzheimer’s Association (not funded yet: Appeal in progress)
The purpose of the project is to perform a systematic review on the traditional vs. complementary medicine treatment for Alzheimer’s disease.
Speaking Invitations
2003
• Evidence-Based Research: A Bayesian Approach -- Implications for Mind/Body Studies in Dentistry
41 st Bayesian Conference, Van Nuys, CA
• Evidence-Based Research in Dentistry
Odontic Seminar, University of Southern California
• Evidence-Based Dentistry
Odontic Seminar, National University at San Diego
• Evidence-Based Dentistry: What is it and How to do it right
Weintraub Center for Reconstructive Dentistry, UCLA
• Evidence-Based Dentistry: Implications and Application in the Context of a Rehab Center
Rancho Los Amigos County Hospital, Los Angeles, CA
• Evidence-Based Research in Dentistry
University of Southern California, Scholl of Dentistry
•Applications and Implications of Evidence-Based Dentistry
Korean-American Dental Association, Los Angeles, CA
• Tools and Methods for Evidence-Based Research in Dental Practice: Preparing the Future.
1 st Int Conf Evidence-Based Dental Practice, Atlanta, GA
2004
• Stress in Dentistry: What is it and what can we do about it?
Odontic Seminar, University of Southern California
• Using the literature to guide clinicians and patient decision-making
2 nd Annual Integrative Medicine Symposium; UCLA
• Stress in Dentistry: Is there a role for evidence-based research
Odontic Seminar, National University at San Diego
Recent Publications
- Chiappelli F, Prolo P, Newman M, Cruz M, Sunga E, Concepcion E, Edgerton M. Evidence-based dentistry: Benefit or hindrance. Journal of Dental Research, 2003, 82:6-7.
- Maekawa K, Twu C, Lotaif A, Chiappelli F, Clark G. Function of -adrenergic receptor on mononuclear cells in female Fibromyalgia patients – Preliminary report. 2003, Journal of Rheumatology, 2003, 30:364-8. (Chiappelli co-I)
- Chiappelli F, Prolo P. Evidence-Based Dentistry and Translational Research. Journal of Evidence Based Dental Practice, 2003, 3:5-7.
- Patel T, Park SH, Lin L, Chiappelli F, Huang GT-J. Substance P induces interleukin-8 production from human dental pulp cells. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 2003, 96:478-85 (Chiappelli co-I)
- Prolo P, Chiappelli F, Bernard G, Fiala M, Ibarra A, Sartori ML, Dovio A, Angeli A. Neuro-immune surveillance of osteosarcoma: emerging hypotheses. Journal of Dental Research, 2003, 82:417-21. (Chiappelli, senior)
- Wong J, Prolo P, Chiappelli F. Extending Evidence-Based Dentistry Beyond Clinical Trials:Implications for Materials Research in Endodontics. Brazilian Journal of Oral Sciences, 2003 2:227-31. Chiappelli, senior)
- Prolo P, Weiss D, Edwards W, Chiappelli F. Appraising the evidence and applying it to make wiser decisions. Brazilian Journal of Oral Sciences, 2003 2:200-3. (Chiappelli, senior)
- Chiappelli F, Prolo P. Evidence-based research in dentistry for the next decade. Brazilian Journal of Oral Sciences, 2003 2:176-8.
- Chiappelli F, Cajulis OS. Psychobiological views on “stress-related oral ulcers”. Quintessence International, 2004, 35:223-7.
- Graves MC, Fiala M, Dinglasan LAV, Liu NQ, Sayre J, Chiappelli F, van Kooten C, Vinters HV. Inflammation in amyotrophic lateral sclerosis spinal cord and brain mediated by activated macrophages, mast cells and T cells. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases, 2004; In Press (Chiappelli co-I).
- Prolo P, Chiappelli F, Harper SR, Neagos N, Fiala M, Grasso E, Mondino F, Rosso MG, Fanto’ F, Masera MG, Sartori ML, Dovio A, Angeli A. Profile of cytokines and Amyloid- in saliva: Putative markers of probable Alzheimer's Disease. Brain Aging, 2004, (In press). (Chiappelli, senior)
- Chiappelli F, Prolo P, Negoatis N, Lee A, Milkus V, Bedair D, Delgodei S, Concepcion E, Crowe J, Termeie D, Webster R. Tools and Methods for Evidence-Based Research in Dental Practice: Preparing the Future. 1 st Int Conf Evidence-Based Dental Practice, Proceedings, Journal of Evidence Based Dental Practice, 2004 4:16-23.
- Duncan R, Shapshak P, Page JB, Chiappelli F, Messiah SE, McCoy CB. Crack Cocaine: Effect modifier of RNA viral load and CD4 count in HIV RNA viral load and CD4 count in HIV infected African American women. Journal of AIDS, 2004 (In press). (Chiappelli co-I)
- Fiala M, Kermani-Arab V, Patel A, Tsao G, Sayre J, Gustavson A, Dinglasan LA, Chiappelli F, Cashman J, Graves MC, Masterman D. Immune activation and abnormal phagocytosis of Alzheimer’s disease patients. Neurobiology of Aging, 2004 In press. (Chiappelli co-I)
- Iribarren J, Prolo P, Neagos N, Chiappelli F. Post-Traumatic Stress Disorder: Research in the Third Millennium. Evidence-Based Complementary and Alternative Medicine, 2004 (In press, pending revisions). (Chiappelli, senior).
- Fiala M, Lin J, Ringman J, Kermani-Arab V, Gustavson A, Sayre J, Sofroni E, Tran E, Artinger E, Patel A, Tsoa G, Graves MC, Chiappelli F, Bernard G. Abnormal macrophage phagocytosis of amyloid-β and neuronal chemokine expression of Alzheimer’s disease patients. Journal ofNeuroscience Research, 2004 (In press, pending revisions) (Chiappelli, co-investigator)
Contact Information:
Francesco Chiappelli, Ph.D.
UCLA School of Dentistry
Box 951668
Los Angeles, CA 90095-1668
On-campus mail: 63-090 CHS 166815
Tel: (310) 794-6625
Fax: (310) 794-7109
E-mail:
Web: www.pnigroup.org
