|About Us :||Faculty :||Naliboff|
|Bruce D. Naliboff, Ph.D.
Clinical Professor, Department of Psychiatry and Biobehavioral Sciences, at the
David Geffen School of Medicine, UCLA
Co-Director, UCLA Center for Integrative Medicine
Director, Human Physiological Reserach, CNS: Center for Neurovisceral Sciences and Women's Health, UCLA Division of Digestive Diseases
Chief, Psychophysiology Research Laboratory, VA Greater Los Angeles Healthcare System
Senior Research Scientist, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute
Dr. Naliboffs research has focused on psychophysiological mechanisms of stress and pain. Past studies have addressed how stress impacts the immune system, glucose regulation in diabetes, and cardiovascular variables. He has also studied psychosocial and personality variables in chronic pain and especially their impact on treatment choice and outcome.
|Dr. Naliboff conducts etiologic and treatment
studies of functional gastrointestinal disorders such as Irritable Bowel
Syndrome (IBS). These include perceptual, autonomic, and brain imaging
studies of visceral sensation, and the role of psychosocial variables
in the presentation, course and treatment of IBS. A major emphasis of
his current work is the relationship between central stress mechanisms
and both somatic and visceral pain disorders. Another area of interest
is in the relationship between anxiety and symptoms in chronic pain disorders.
Dr. Naliboff has NIH funding to study gender differences in central responses
to visceral sensation as well as the role of visceral specific anxiety
in Irritable Bowel Syndrome. He has recently begun a clinical trial comparing
several psychological treatments for IBS and has an ongoing clinical
trial of opioid medications in of chronic pain. He collaborates with
other UCLA investigators on studies of neuroendocrine and immune factors
in pain conditions such as IBS and fibromyalgia.
Health Outcomes from Opiate Therapy for Chronic
Treatment of Pain and Fear in Irritable Bowel
Naliboff BD, Solomon GF, Gilmore S, Benton D, Fahey JL, Pine J. Rapid changes in cellular immunity following a confrontational role-play stressor. Brain Behavior and Immunity 9: 207-219, 1995.
Lembo A, Naliboff BD, Matin K, Munakata J, Parker R, Gracely R, Mayer EA. Irritable bowel syndrome patients show altered sensitivity to exogenous opioid. Pain, 1195-1200, 2000.
Naliboff BD, Derbyshire SWG, Munakata J, Berman S, Mandelkern M, Chang L, Mayer EA. Cerebral activation in irritable bowel syndrome patients and control subjects during rectosigmoid distension. Psychosomatic Medicine, 63: 365-375, 2001.
Cole SW, Naliboff BD, Kemeny ME, Griswold M, Fahey JL, & Zack JA. Impaired response to HAART in patients with high autonomic nervous system activity. PNAS USA, 98, 12695-12700, 2001.
Chang L, Munakata J, Naliboff B, Saba L, Matin K, Bernstein C, Anton PA, Mayer EA. Perceptual responses in patients with inflammatory and functional bowel disease. Gut, 47:497-505, 2000.
Bruce D. Naliboff, Ph.D.