|About Us :||Faculty :||Martinez|
Otoniel Martínez-Maza, PhD
Research Interests and Current Projects:
A major objective of Dr. Martínez-Maza’s work over the last several years has been to define HIV infection-associated immune system changes that precede, and contribute to, AIDS-associated non-Hodgkins
B cell lymphoma (AIDS-lymphoma). This includes studies to determine if elevated levels of B cell-stimulatory cytokines precede the development of AIDS-lymphoma, and/or if polymorphisms in the genes encoding B cell-stimulatory cytokines are associated with an elevated risk for the development of AIDS-lymphoma. In recent work, it was seen that elevated IL10 production, as well as a genetic predisposition toward higher production of IL10 (an IL10 promoter SNP at -592 associated with relatively higher expression of this cytokine), were risk factors for the development of AIDS-lymphoma. In other work, his group is examining the role of activation-induced cytidine deaminase (AICDA) in the pathogenesis of AIDS-lymphoma. In recent work, an AICDA splice variant was identified, and current studies aim to better identify its function. Additionally, the induction of AICDA expression by human viruses (EBV) is being explored. Finally, Dr. Martínez-Maza also is involved in studies to better define the role of immune dysfunction in the pathogenesis of gynecologic cancers, including those associated with human papillomavirus (HPV) infection.
Dr. Martínez-Maza is actively involved in several national and international multicenter studies of cancer, or AIDS and HIV infection. He serves as the Chairman of the Malignancies Working Group in the Multicenter AIDS Cohort Study, and participates in the AIDS Malignancies Consortium and in Interlymph, an international consortium of researchers with an interest in the epidemiology and pathogenesis of lymphoma. In addition to this, he is the director of the NIH/Fogarty-funded AIDS-malignancies supplemental program supporting international training and research in this area.