|About Us :||Faculty :||Fanselow|
|Michael S. Fanselow,
Professor, UCLA Department of Psychology Area Chair, Learning and Behavior
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute
Dr Fanselow's laboratory uses rat and mouse models employing anatomical, pharmacological and genetic alterations to understand the neurobiology of basic motivational, emotional and learning systems. He is particularly interested in fear and anxiety and how it interacts with pain and illness induced recuperative behavior. Fear is a coordinated system involving the amygdala and periaqueductal gray that is organized to protect against environmental threats. When it is activated it
engages opioid mediated analgesic systems to inhibit recuperative behavior. Cytokine activation engages recuperative behavior that while beneficial to recovery, can interfere with overt defenses. The balance between these systems is controlled by glutamatergic, GABAergic and opioidergic neurotransmission in specific neural circuits.
Anterograde Amnesia for Contextual Fear NIMH
R01 MH62122-02 active
Center for the Study of Opioid Receptors and
Drugs of Abuse DA-05010 Active
Retrograde Amnesia for Trace Fear Conditioning
Petrie J, Sapp DW, Tyndale RF, Park MK, Fanselow MS, Olsen RW. Altered GABA(A) receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Alcoholism-Clinical and Experimental Research, 25, 819-828, 2001.
Wiltgen, B. J., Sanders, M. J., Behne, N. S., & Fanselow, M. S. Sex differences. Context preexposure, and the immediate shock deficit in Pavlovian context conditioning with mice. Behavioral Neuroscience, 115, 26-32, 2001.
Fanselow, M. S. Contextual fear, gestalt memories, and the hippocampus. Behavioural Brain Research, 110, 73-81, 2000.
Fanselow, M. S., & Gale, G. D. Amygdala. In G. Fink (ed.), Encyclopedia of Stress, 1, 178-182. San Diego: Academic Press, 2000.
Godsil, B. P., Quinn, J. J., & Fanselow, M. S. Body temperature as a conditional response measure for Pavlovian fear conditioning. Learning & Memory, 7, 353-356, 2000.
Fendt, M. & Fanselow, M. S. The neuroanatomical and neurochemical basis of conditioned fear. Neuroscience & Biobehavioral Reviews, 23, 743-760, 1999.
Li, H. H., Yu, W.-H., Rozengurt, N., Zhao, H.-Z., Lyons, K. M., Anagnostaras,
S., Fanselow, M. S., Suzuki, K., Vanier, M. T., Neufeld, E. F. Mouse
model of Sanfilippo syndrome type B produced by targeted disruption
of the gene encoding alpha -N-acetylglucosaminidase Proceedings of
the National Academy of Sciences, USA, 96, 14505-14510, 1999.
Mihalek, R. M., Banerjee, P. K., Korpi, E. R., Quinlan, J. J., Firestone, L. L., Mi, Z.-P., Lagenaur, C., Tretter, V., Sieghart, W., Anagnostaras, S. G., Sage, J. R., Fanselow, M. S., Guidotti, A., Spigelman, I., Li, Z., DeLorey, T. M., Olsen, R. W., Homanics, G. E. Attenuated sensitivity to neuroactive steroids in gamma -aminobutyrate type A receptor delta subunit knockout mice Proceedings of the National Academy of Sciences, USA., 96, 12905-12910, 1999.
DeLorey, T. M., Handforth, A., Anagnostaras, S. G., Homanics, G. E., Minassian, B. A., Asatourian, A., Fanselow, M. S., Delgado-Escueta, A., Ellison, G. D., & Olsen, R. W. Mice Lacking the beta 3 Subunit of the GABAA Receptor Have the Epilepsy Phenotype and Many of the Behavioral Characteristics of Angelman Syndrome. Journal of Neuroscience, 18, 8505-8514, 1998.
Bolles, R.C. & Fanselow, M.S. A perceptual-defensive-recuperative model of fear and pain. Behavioral & Brain Sciences, 3, 291-301, 1980.
Michael S. Fanselow, Ph.D.