|About Us :||Faculty :||Butch|
|Anthony W. Butch, Ph.D.
Associate Professor, Department of Pathology & Lab Medicine, UCLA Medical Center, Los Angeles, CA.
Director of Chemistry, Toxicology, Immunochemistry, and Support Services,
Clinical Laboratories at the UCLA Medical Center, Los Angeles, CA.
Director of Clinical Immunology Research Labs, UCLA Medical Center, Los Angeles, CA.
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute
Dr. Butch is interested in understanding how antigen-presenting dendritic cells regulate immunity and inflammatory responses in various microenvironments.
Earlier work investigated molecular mechanisms by which human follicular dendritic cells regulate T cell responses in germinal centers of lymphoid tissue. Collaborative studies are currently underway with Dr. Kelly to evaluate the role of dendritic cells in generating immunity in various mucosal tissues using a mouse model of Chyamydia infection. Other areas of research involve the characterization of assays to evaluate immune function and the development of immuoassays against novel proteins. Recent work in collaboration with Dr. Gatti has resulted in the development of a sandwich immunoassay to quantitate cellular levels of the ataxia-telangiectasia mutated (ATM) protein. ATM protein is absent or found in extremely small quantities in mononuclear cells from patients with the progressive neurodegenerative disorder ataxia-telangiectasia.
Core Immunology Laboratory
Principle Investigator: A. Butch
Natural History of AIDS in Homosexual Men
Principle Investigator: R. Detels
T-Cell Mediated Immunity in Chlamydial Infection
Principle Investigator: K. Kelly
Cancer Center Core Support Grant
Principle Investigator: J. Gasson
Butch AW, Fukuchi AM. Analytical performance of the CEDIA cyclosporine PLUS whole blood immunoassay. J Anal Toxicol. 2004;28:204-10.
McWhorter VC, Ford LC, Butch AW. Analytical performance of the Synchron LX ®20 Pro, BN TMII and IMMAGE ® high sensitivity C-reactive protein assays and concordance in cardiovascular risk stratification. Clinica Chimica Acta. 2004;374:71-9.
Jahr JS, Osgood S, Rothenberg SJ, Steien E, Li QL, Bezdikian V, Butch AW, Gunther R, Cheung A, Driessen B. Lactate interference by hemoglobin-based oxygen carriers (Oxyglobin ®, Hemopure ®, and Hemolink TM). Anesth Analg., in press.
Wah DT, Wises PK, Butch AW. Analytical performance of the iQ200 ® automated urine microscopy analyzer and comparison with manual counts using Fuchs-Rosenthal cell chambers. Am J Clin Path., in press.
Aziz N, Irwin MR, Dickerson SS, Butch AW. Spurious tumor necrosis factor alpha and interleukin-6 production by human monocytes from blood collected in endotoxin-contaminated Vacutainer blood collection tubes. Clin Chem., in press.
Butch AW, Chun HH, Nahas SA, Gatti RA. Development of an immunoassay to measure ataxia-telangiectasia mutated (ATM) protein in cellular lysates. Clin Chem., in press.