|About Us :||Faculty :||Anton|
|Peter Anton, M.D.
Associate Professor, Department of Medicine
Division of Digestive Diseases, at the David Geffen School of Medicine, UCLA;
Director, UCLA Center for HIV and Digestive Diseases
Co-Director, UCLA Inflammatory Bowel Disease (IBD) Center
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute
In collaboration with Dr. Goldring, Taylor and Kemeny, Dr. Anton has studied the impact of health beliefs, quality of life and the physician-patient relationship on the treatment intentions of inflammatory bowel disease patients.
The research tested a model of treatment decision-making in chronic illness that includes health beliefs, quality of life (disease activity and functional impairment), and relationship with the physician (shared or not). The findings suggest that an integrative consideration of relationship factors, health beliefs, and health status may help explain treatment intentions among the chronically ill. Other studies with Dr. Tache have investigated the role of central neuropeptides in an animal model of inflammatory bowel disease as a member of the PNI Task Force for the Cousins Center for PNI since 1990 For the past 7 years, his research has focused primarily on HIV pathogenesis in the gastrointestinal mucosa and prevention strategies.
Impact of co-receptor and HIV viral burden
on gut mucosa
The aims of the project are to optimize HIV quantitative tissue assays using endoscopic biopsies and characterization of mucosal mononuclear cells in the setting of HIV infection. The tools are to be used to correlate tissue viral burden with co-receptor expression in mucosa and investigate in vitro susceptibility to infection of mucosal cells from healthy and inflamed biopsies from HIV-negative subjects. Interventional trials using anti-inflammatory agents are planned. Mentoring is a large component of this project.
UCLA Center for AIDS Research (CFAR) Core
for Mucosal Immunology
The major goal of this project is to assist the development of HIV-related mucosal immunology projects as a Core facility including study design, patient access, assistance in IRB applications and tissue acquisition. This funding assists in providing the infrastructure for investigator access to mucosal tissue by supporting the development of reproducible methods for intestinal biopsy tissue acquisition and sample preparation.
Chang L, Munakata J, Naliboff B, Saba L, Matin K, C Bernstein C, Anton PA, Mayer EA. Perceptual responses in patients with inflammatory and functional bowel disease. Gut, 47:497-505, 2000.
Cole S, Kemeny ME, Weitzman ME, Schoen M, Anton PA. Socially inhibited individuals show heightened DTH response during intense social engagement. Brain, Behavior and Immunity, 13(2):187-200, 1999.
Mulugeta M, Tache Y, Anton PA. Chronic stress worsens TNB colitis in Lewis rats: The protective role of brain CRF. Am J Physiol, 276:G1016, 1999.
Million M, Taché Y and Anton PA. Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF Am J Physiol, 276: G1027- G1036, 1999.