Substance Dependence: Biobehavioral Mechanisms and Infectious Disease Risk

Here is what our Cousins Center investigators have accomplished:

Abnormalities of sleep and cytokine responses may explain disparities in health in recovering alcoholics: increased risk in African American alcoholics:
Irwin M, Miller C: Decreased natural killer cell responses and altered interleukin-6 and interleukin-10 production in alcoholism: an interaction between alcohol dependence and African-American ethnicity. Alcoholism: Clinical and Experimental Research 24:560-569, 2000.
Irwin M, Miller C, Gillin JC, Demodena A, Ehlers C: Polysomnographic and spectral sleep EEG in primary alcoholics: an interaction between alcohol dependence and African-American ethnicity. Alcoholism Clinical Experimental Research 24:1376-1384, 2000.
Alcoholics show a defect in the homeostatic regulation of sleep with impacts on immunity:
Irwin M, Gillin JC, Dang J, Weissman J, Phillips E, Ehlers CL: Sleep deprivation as a
probe of homeostatic sleep regulation in primary alcoholics. Biological Psychiatry 51:632-641, 2002.
Redwine L, Dang J, Hall M, Irwin M: Disordered sleep, nocturnal cytokines and immunity in alcoholics. Psychosomatic Medicine. 65:75-85, 2003.
Alcoholics are at increased risk of infectious disease complications following surgery due to a dysregulation of cytokines:
Sanders M, Irwin M, Sinha P, Naumann E, Kern H, Kox WJ, Spies CD: Suppresion of Interleukin-6 to interluekin-10 ratio in chronic alcoholics: association with postoperative infections. Intensive Care Med 28:285-292, 2002.
Novel Orphanin Transcripts Are Expressed In Human Immune Cells:
Arjomand J, Cole S& Evans CJ. Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells. J Neuroimmunol. 2002 Sep;130(1-2):100-8
Cocaine dysregulates cytokine expression and enhances HIV replication
Gan X, Zhang L, Newton T, Chang SL, Ling W, Kermani V, Berger O, Graves MC, Fiala M. Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects. Clin Immunol Immunopathol. 1998 Nov;89(2):181-90.
Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. J Infect Dis 2002 Mar 1;185(5):701-5
Alcohol impair the bidirectional communication between the immune system and the brain:
Taylor AN, Tio DL, Heng NS, Yirmiya R. Alcohol consumption attenuates febrile responses to lipopolysaccharide and interleukin-1 beta in male rats. Alcohol Clin Exp Res. 2002 Jan;26(1):44-52.
Sanders M, Irwin M, Sinha P, Naumann E, Kern H, Kox WJ, Spies CD: Suppresion of Interleukin-6 to interluekin-10 ratio in chronic alcoholics: association with postoperative infections. Intensive Care Med 28:285-292, 2002.
See what we are doing now. Here are some of our ongoing studies:
Center for Study of Opioid Receptors and Drugs of Abuse (CSORDA)
Principal Investigator: Christopher Evans, Ph.D.

Fetal Alcohol Exposure: Neuroimmune Interactions - Click Here
Principal Investigator: Anna N. Taylor

Alcoholism: Sleep and Cytokines - Click here
Michael Irwin, Principal Investigator
Cocaine: Sleep and Cytokines - Click here
Michael Irwin, Principal Investigator
Research : Sponsored Studies : Alcoholism and Substance Abuse
Overview
Study Participation
Sponsored Studies
Seed Grant Program
Core Laboratories