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About Us : Faculty : Chiappelli
Francesco Chiappelli, Ph.D.
Professor, UCLA School of Dentistry
Division of Oral Biology and Medicine, Laboratory of Human Oral and Molecular Immunology
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute


Research Interests

Dr. Chiappellis research is focused on psycho-neuroendocrine-immune interactions in the domain of stomatological diseases. He is particularly interested in the neuroimmunology of pain (e.g., tempomandibular disorders), and in pathologies of the soft mucosa, such as oral lichen planus. He investigates alteration in the pattern of autonomic innervation in these lesions as they transform to become oral carcinoma lesions, as well as in osteosarcoma. He is also actively pursuing research on neuroendocrine-immune relationships in psychiatric diseases, such as Alzheimers disease, and in conditions of psychoemotional stress, including caregiving to patients with Alzheimers disease. Lastly, they are examining the cutting edge area of investigative endeavor in dental research, which pertains to the identification, evaluation and analysis of the best available evidence. They seek to characterize the optimal modalities for evidence based dentistry, and to explore potential application and implications to the novel domain of evidence based psychoneuroimmunology.

Current research

Molecular Biology of T Cell Memory in Alzheimer's Disease
Principal Investigator: F. Chiappelli
Agency: Alzheimer's Association
Type: IIRG-92-1652 Period: 07/01/00-06/30/03

The major goal of this project is to study the molecular events that determine the mechanisms of modulation of T cell memory formation by beta-Amyloid and in patients with probable Alzheimer's disease.

Cocaine and HIV in coronary endothelium
Co-Investigator
Principal Investigator: M. Fiala
Agency: NIH, NHLB
Type: R01 HL63065 Period: 05/01/99-04/30/04

The major goal of this project is to study the molecular events that determine the mechanisms of modulation of migration of immune cells through endothelium by drugs of abuse (e.g., cocaine) in HIV disease.

Alcoholism and brain-immune interactions
Co-Investigator
Principal Investigator: AN Taylor
Agency: VAMC
Type: Merit Review no number Period: 10/01/01-09/30/06

The major goal of this project is to study the molecular events that determine the mechanisms of modulation of brain-immune interaction (i.e., cellular immune-pituitary-adrenal axis) by alcohols (e.g., ethanol) and in alcohol abuse disease.

Alcohol abuse, blood-brain barrier and HIV invasion
Co-Investigator
Principal Investigator: M. Fiala
Agency: NIAA
Type: no number Period: 07/01/02-06/30/07

The major goal of this project is to study the molecular events that determine the mechanisms of modulation of migration of immune cells through endothelium by alcohol in HIV disease.

Recent publications

Chiappelli F, Prolo P. Evidence based dentistry for the 21st Century. General Dentistry, 2002, 50:270-3.
Chiappelli F, Prolo P. The meta-construct of evidence based dentistry: Part II. Journal of Evidence Based Dental Practice, 2002, 2:1-7.
Chiappelli F, Concepcion E, Sunga E, Prolo P. Cross-cultural implications of evidence based dentistry. Brazilian Journal of Oral Sciences, 2002, 1:47-53
Chiappelli F, Bauer J, Spackman S, Prolo P, Edgerton M, Armenian C, Dickmeyer J, Harper S. Dental needs of the elderly in the 21st Century. General Dentistry, 2002, 50:358-63
Masera RG, Prolo P, Staurenghi A, Sartori ML, Griot G, Lazzero A, Ravizza L, Chiappelli F, Angeli A. Mental deterioration correlates with response of natural killer (NK) cell activity and to physiological modifiers in patients with short history of Alzheimers disease. Psychoneuroendocrinology, 2002, 27:447-61.
Chiappelli F, Cajulis OS. Intra-arterial injections. Journal of American Dental Association, 2002, 133:1166-70
Chiappelli F, Prolo P, Newman M, Cruz M, Sunga E, Concepcion E, Edgerton M. Evidence-based dentistry: Benefit or hindrance. Journal of Dental Research, 2003, 82:6-7.
Maekawa K, Twu C, Lotaif A, Chiappelli F, Clark G. Function of ?-adrenergic receptor on mononuclear cells in female Fibromyalgia patients Preliminary report. 2003, Journal of Rheumatology, In Press
Chiappelli F, Concepcion E, Sunga E, Wong J, Prolo P. Number needed to treat (NNT): Benefit or hindrance in evidence-based dental practice. Brazilian Journal of Oral Sciences, 2003, In Press
Bauer, JG, Chiappelli F, Spackman S, Prolo P, Edgerton M. Dementia of the Alzheimers type: A growing service population for dentistry. Long-Term Care Interface, 2003, In Press
Chiappelli, F, Prolo, P. Evidence-Based Dentistry and Translational Research. Journal of Evidence Based Dental Practice, 2003, In Press.
Patel, T, Park, SH, Lin, L, Chiappelli, F, Huang, GT-J. Substance P Induces Interleukin-8 Production from Human Dental Pulp Cells. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2003. In press.

Francesco Chiappelli, Ph.D.
UCLA School of Dentistry
Box 951668
Los Angeles, CA 90095-1668
On-campus mail: 63-090 CHS 166815
Tel: (310) 794-6625
Fax: (310) 794-7109
E-mail: [email protected]
Web: www.pnigroup.org

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